Spectroscopic pathology research can be done with microspectrophotometers using reflectance, absorbance and fluorescence microspectroscopy and imaging.
Ultraviolet image of a cell
Spectroscopic pathology can use microspectrophotometers to eamine tissues on the microscopic scale.
Spectroscopic pathology is the study of disease by examining the spectroscopic characteristics of tissues and bodily fluids. Biomarkers are analyzed either directly in the tissue or fluid or with the aid of taggant molecules. An example of the latter would be a fluorescent immunoassays of tissues. Spectroscopic pathology is being developed to aid the pathologist in identifying diseases in tissues and fluids by analyzing and comparing the spectra of the diseased versus the healthy samples. It has been shown that some types of diseased tissue can be directly identified by their spectrum while others can be tagged and then located and identified.
Microspectrophotometers, such as the 20/30 PV™, are able to measure the UV-visible-NIR range spectrum of microscopic areas of tissue samples in absorbance, reflectance and even fluorescence. Combined with automated stages, these systems could map out the spectral characteristics of tissue samples with very high spatial and spectral resolution. Additionally, such microspectrophotometers are also able to directly image the biological samples from the deep UV to the NIR yielding even faster diagnostic techniques.
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